Folate, also known as folic acid, vitamin B-9, vitamin M, VitaminBc; has come a long way since its discovery, evolving into a vital supplement for overall health. Discovered in the early 20th century, folate plays a crucial role in DNA synthesis and repair, making it essential for cell division and growth. The discovery paved the way for using folic acid as a supplement, especially during pregnancy to prevent neural tube defects.

Over the years, research has expanded, revealing folate's broader health implications especially on Cardiovascular and cognitive functions in related to the elevated Homocysteine levels in human body.

Homocysteine and its Cardiovascular Threat

Homocysteine, an amino acid produced in the body, has emerged as a significant cardiovascular risk factor. Elevated levels of homocysteine are associated with an increased risk of heart disease, stroke, and other cardiovascular issues. Research indicates that homocysteine contributes to atherosclerosis, a condition characterized by the hardening and narrowing of arteries, leading to an increased risk of heart attacks and strokes. Studies indicate that people with homocysteine values greater than 8.5 µmol/L are at increased risk of atherosclerosis, heart attack, and stroke.

While the exact mechanisms linking homocysteine to cardiovascular issues are still under investigation, it is clear that maintaining optimal homocysteine levels is crucial for heart health.

Folic Acid's Role in Cardiovascular Health

Folic Acid plays a pivotal role in cardiovascular health by helping to regulate homocysteine levels. The conversion of homocysteine to methionine, a non-toxic amino acid, is facilitated by folic acid. Statistics had shown in a study between 1998-2002, the introduction of mandatory folic acid fortification in the US and Canada in 1998 led to increased blood folate concentrations and decreased homocysteine concentrations, resulting in a significant decline in stroke-related mortality. Researchers concluded adequate folic acid levels are crucial for the homocysteine conversion process, highlighting the importance of incorporating folic acid into our diets or through supplements.

L-5-Methylfolate: The Superior Form for Homocysteine Control

However, recent studies shows that many people find their homocysteine levels stubbornly resist even high doses of folic acid. Up to half of all Americans may carry a genetic variation that prevents the body, including the brain, from optimally using folic acid. L-5-methylfolate, the active form of folic acid, that consists of an enzyme called methylenetetrahydrofolate reductase or MTHFR, and makes L-5-methylfolate more absorbable compared to synthetic folic acid. In other words, L-5-methylfolate bypasses metabolic steps, ensuring a more efficient conversion of homocysteine to methionine. Individuals who struggle with the conversion process may benefit significantly from L-5-methylfolate supplementation. Animal and clinical studies have proven that L-5-methylfolate is more effective than folic acid at increasing serum active folate levels, which not only significantly showed to lower homocysteine level and C-reactive protein but also improve human survival.

L-5-methylfolate’s suggested daily dosage

A daily dose of 800-1,000 mcg (0.8 to 1.0 mg) L-5-methylfolate plus Vitamin B 6 and Vitamin B12 is typically used in research studies to achieve clinically beneficial reduction in elevated plasma homocysteine concentrations. Even doses of 200-400 mcg (0.2 to 0.4 mg) have been shown to achieve the health benefits.

Life Nutrition's Advanced Multivitamins with L-5-Methylfolate

Life Nutrition’s Women's Everyday Complete and Men's Everyday Complete include 59 essential vitamins, minerals, and super antioxidants, with complete suggested daily dosage of a patented L-5-methylfolate, vitamin B6 and B12 to provide the optimal holistic health benefits, supporting cardiovascular health among other key functions.